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Products Details
Product Description
– PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM)[1].
Web ID
– HY-144684
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H22BNO4
References
– [1]Joseph Walter Strohbach, et al. Inhibiteurs de pde4 contenant du bore. WO2020070651A1.
CAS Number
– 2415085-45-7
Molecular Weight
– 327.18
SMILES
– CCCOC1=C(OC)C=CC(C2=CN=CC([C@]3([H])CB(OC3)O)=C2)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Interleukin Related;Phosphodiesterase (PDE)
Isoform
– IL-13;IL-4;PDE4
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
