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Products Details
Product Description
– PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC50s of 0.125 and 0.43 µM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects[1].
Web ID
– HY-115913
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H20FNO5S
References
– [1]Thirupataiah B, et al. Fe(III)-catalyzed regioselective and faster synthesis of isocoumarins with 3-oxoalkyl moiety at C-4: Identification of new inhibitors of PDE4. Bioorg Chem. 2022;121:105667.
Molecular Weight
– 465.49
SMILES
– CC(CCC1=C(OC(C2=CC(F)=CC=C21)=O)C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CC=C3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– PDE4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
