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Products Details
Product Description
– PDE4-IN-5 (compound 33a) is a potent and selective PDE4 inhibitor (IC50=3.1 nM). PDE4-IN-5 has favorable skin permeability and a well-characterized binding mechanism. Anti-psoriasis effect[1].
Web ID
– HY-144265
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H28N2O3
References
– [1]Song Z, et al. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J Med Chem. 2022;65(5):4238-4254.
CAS Number
– 2768626-06-6
Molecular Weight
– 356.46
SMILES
– O=C1N(C2=NC(C)=CC=C2C3=C1[C@@H](C[C@@](C)(O3)CCO)/C=C(C)C)CC
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– PDE4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
