Products Details

Product Description

– PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled research of pulmonary diseases.

Web ID

– HY-115871

Shipping

– Room temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C36H37Cl2N3O7S

References

– [1]Armani E, et al. Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2021 Jul 8;64(13):9100-9119.

CAS Number

– 1793069-00-7

Molecular Weight

– 726.67

SMILES

– O=C(C1=CC=C(CN[C@H](C2=CC=CC=C2)C(O[C@H]3CN4CCC3CC4)=O)S1)O[C@H](C5=CC=C(OC)C(OC)=C5)CC6=C(Cl)C=[N+]([O-])C=C6Cl

Clinical Information

– No Development Reported

Research Area

– Others

Solubility

– 10 mM in DMSO

Target

– mAChR;Phosphodiesterase (PDE)

Isoform

– mAChR3;PDE4

Pathway

– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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