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Products Details
Product Description
– PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research[1][2][3].
Web ID
– HY-150060
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H19FN2O2
References
– [1]Denholm A, et al. Preparation of naphthyridines as phosphodiesterase isoenzyme 4 (PDE4) inhibitors: World Intellectual Property Organization, WO2003039544[P]. 2003-05-15.|[2]McCarthy C, et al. Use of naphthyridine derivatives as medicaments for the treatment of pulmonary hypertension: World Intellectual Property Organization, WO2007088019[P]. 2007-08-09. |[3]Press NJ, et al. Organic compounds for treating pulmonary hypertension: World Intellectual Property Organization, WO2009013286. 2009-01-29.
CAS Number
– 524734-30-3
Molecular Weight
– 350.39
SMILES
– O=C(C1CCC(CC1)C2=CC3=C(N=CC=C3)C(C4=CC=CC(F)=C4)=N2)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– PDE4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
