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Products Details
Product Description
– PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro[1].
Web ID
– HY-147950
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H13N
References
– [1]Bta B, et al. Synthesis of 11,12-dihydro benzo[c]phenanthridines via a Pd-catalyzed unusual construction of isocoumarin ring/FeCl3-mediated intramolecular arene-allyl cyclization: First identification of a benzo[c]phenanthridine based PDE4 inhibitor – ScienceDirect. Bioorganic Chemistry. April 2020;97:103691.
CAS Number
– 2413564-66-4
Molecular Weight
– 243.30
SMILES
– CC1=CC2=C3C=CC=CC3=CN=C2C4=CC=CC=C14
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE);TNF Receptor
Isoform
– CD40;PDE4
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
