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PD-166866
$33 – $740
Products Details
Product Description
– PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.
Web ID
– HY-101296
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H24N6O3
References
– [1]Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77.|[2]Thompson AM, Connolly CJ, Hamby JM, et al. 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. J Med Chem. 2000;43(22):4200-4211.
CAS Number
– 192705-79-6
Molecular Weight
– 396.44
Compound Purity
– 99.89
SMILES
– O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Autophagy;FGFR
Isoform
– FGFR1
Pathway
– Autophagy;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
