PD-166866

$33$740

Products Details

Product Description

– PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.

Web ID

– HY-101296

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C20H24N6O3

References

– [1]Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77.|[2]Thompson AM, Connolly CJ, Hamby JM, et al. 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. J Med Chem. 2000;43(22):4200-4211.

CAS Number

– 192705-79-6

Molecular Weight

– 396.44

Compound Purity

– 99.89

SMILES

– O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– Autophagy;FGFR

Isoform

– FGFR1

Pathway

– Autophagy;Protein Tyrosine Kinase/RTK

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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