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Products Details
Product Description
– PD-1/PD-L1-IN-18 (Compound L31) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-18 blocks PD-1/PD-L1 with the IC50 of 1.054 μM. Antitumor Activity[1].
Web ID
– HY-145768
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H32BrCl2N3O4
References
– [1]Liu Liu, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[ c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021 Jun 24;64(12):8391-8409.
CAS Number
– 2648851-27-6
Molecular Weight
– 685.43
SMILES
– ClC1=C(OCC2=CC=CC(C3=CC=CC=C3)=C2Br)C=C(OCC4=CC5=NON=C5C=C4)C(CNC6CCC(CC6)O)=C1.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PD-1/PD-L1
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
