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PD-1/PD-L1-IN-14
$450 – $3,800
Products Details
Product Description
– PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].
Web ID
– HY-144258
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H24N4O2
References
– [1]Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65(5):3879-3893.
CAS Number
– 2499965-12-5
Molecular Weight
– 400.47
Compound Purity
– 99.85
SMILES
– CC1=C(C2=NN=C(NC3=CC(CNCCO)=CC=C3)O2)C=CC=C1C4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PD-1/PD-L1
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
