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Products Details
Product Description
– PD-1-IN-25 (compound 43) is a potent PD-1/PD-L1 interaction inhibitor with an IC50 value of 10.2 nM in the HTRF assay. PD-1-IN-25 can promote CD8+ T cell activation through inhibiting PD-1/PD-L1 cellular signaling. PD-1-IN-25 delays the tumor growth[1].
Web ID
– HY-157055
Shipping
– Room temperature
Molecular Formula
– C37H35ClF2N2O9
References
– [1]Zilan Song, et al. Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage. J Med Chem. 2021 Nov 25;64(22):16687-16702.
CAS Number
– 2413100-40-8
Molecular Weight
– 725.13
SMILES
– CC1=C(C=CC=C1C(F)(F)OC2=CC(OCC3=CC(C#N)=CC=C3)=C(C=C2Cl)CN[C@H]4[C@H]([C@@H]([C@H](OC4O)CO)O)O)C5=CC=C(OCCO6)C6=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PD-1/PD-L1
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
