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Products Details
Product Description
– PCSK9-IN-3 is a novel, highly potent, and orally bioavailable next-generation tricyclic peptide PCSK9 inhibitor.
Web ID
– HY-139998
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C81H105FN15O15S2.C2HF3O2
References
– [1]Tucker TJ, et al. A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors. J Med Chem. 2021 Nov 25;64(22):16770-16800.
CAS Number
– 2867496-34-0
Molecular Weight
– 1724.94
SMILES
– O=C(N1CC[C@H](OC/C=C/CC2=CC=CC(C[C@H](NC([C@@H](C)NC([C@@H](NC(CCSC3)=O)CNC(CCOCCOCC[N+](C)(C)C)=O)=O)=O)C(N4)=O)=C2)[C@H]1C(N[C@H](C(N[C@H]5CC6=CC=C(OC)C=C6)=O)[C@@H](C)O)=O)[C@@H]4CC7=CN(CC8=CN(C9=CC3=CC(CSCCNC([C@]%10(C)CCCN%10C5=O)=O)=C9)N=N8)C%11=C7C=C(F)C=C%11.[O-]C(C(F)(F)F)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
