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Products Details
Product Description
– PCSK9-IN-13(compound 3f) is a potent PCSK9 inhibitor, which can antagonize low-density lipoprotein (LDL) receptor binding by binding to PCSK9, with an IC50 of 537 nM[1].
Web ID
– HY-148758
Shipping
– Room temperature
Molecular Formula
– C30H33N5O2
References
– [1]Benny J. Evison, et al. A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.Bioorganic & Medicinal Chemistry
CAS Number
– 2244129-23-3
Molecular Weight
– 495.62
SMILES
– O=C(C1=CC(OC2=CC=CC=C2)=C(C=C1)C)NC3=CC(N4C=C(N=C4)C)=CC(CN5C[C@H](CCC5)N)=C3
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
