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Products Details
Product Description
– PARP1-IN-17 is a PARP-1 inhibitor (IC50 = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity[1].
Web ID
– HY-157137
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H27FN4O
References
– [1]Yu L, et al. Discovery of novel 2, 3, 4, 5-tetrahydrospiro [benzo [c] azepine-1, 1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors [J]. BMC chemistry, 2023, 17(1): 147.
Molecular Weight
– 406.50
SMILES
– OC1C2=CC=CC=C2C3(CCCCC3)N(CC4=CN(C5=CC=CC=C5F)N=N4)CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase;PARP
Isoform
– Caspase 3;PARP1
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
