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Products Details
Product Description
– PARP1-IN-17 is a PARP-1 inhibitor (IC50 = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity[1].
Web ID
– HY-157137
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H27FN4O
References
– [1]Yu L, et al. Discovery of novel 2, 3, 4, 5-tetrahydrospiro [benzo [c] azepine-1, 1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors [J]. BMC chemistry, 2023, 17(1): 147.
Molecular Weight
– 406.50
SMILES
– OC1C2=CC=CC=C2C3(CCCCC3)N(CC4=CN(C5=CC=CC=C5F)N=N4)CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase;PARP
Isoform
– Caspase 3;PARP1
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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