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Products Details
Product Description
– PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor, with an IC50 of 1.89 nM. PARP1-IN-16 can arrest the cell cycle in S phase and induce apoptosis in HCT-116 cells[1].
Web ID
– HY-156298
Shipping
– Room temperature
Molecular Formula
– C40H34FN7O5
References
– [1]Wan S, et, al. Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer. Eur J Med Chem. 2023 Oct 6:261:115843.
Molecular Weight
– 711.74
SMILES
– FC(C=CC(CC1=NNC(C2=CC=CC=C21)=O)=C3)=C3C(N4CCN(CC4)C(CCCO/N=C5/C(NC6=CC=CC=C65)=C7C8=C(NC7=O)C=CC=C8)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PARP
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
