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Products Details
Product Description
– PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) [1].
Web ID
– HY-149003
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H23N3O5
References
– [1]Essam Eldin A. Osman, et al. Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors. Bioorg Chem. 2020 Aug; 104: 104198.
CAS Number
– 2494001-21-5
Molecular Weight
– 385.41
SMILES
– O=C1/C(C(N(C)C(N1C)=O)=O)=CC2=CC=C(C=C2)OCC(N3CCCCC3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PARP
Isoform
– PARP1
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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