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Products Details
Product Description
– PARP-2-IN-3 (Compound 12) is a potent PARP-2 inhibitor with an IC50 of 0.07 μM. PARP-2-IN-3 induces apoptosis and necrosis in cancer cells. PARP-2-IN-3 shows appropriate predicted pharmacokinetic parameters and oral bioavailability[1].
Web ID
– HY-151625
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H20ClN3O3
References
– [1]El-Ghobashy NM, et al. Synthesis, biological evaluation, and molecular modeling studies of new benzoxazole derivatives as PARP-2 inhibitors targeting breast cancer. Sci Rep. 2022 Sep 28;12(1):16246.
CAS Number
– 2915650-86-9
Molecular Weight
– 385.84
SMILES
– O=C(NC1=CC=C(C2=NC3=CC(Cl)=CC=C3O2)C=C1)CCN4CCOCC4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PARP
Isoform
– PARP2
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
