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PARP-1-IN-2
$300 – $950
Products Details
Product Description
– PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1].
Web ID
– HY-147027
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H15Cl2N3O2
References
– [1]Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.
CAS Number
– 684234-55-7
Molecular Weight
– 424.28
Compound Purity
– 98.80
SMILES
– O=C(NC1=CC=CC(Cl)=C1)CN(N=C(C2=CC=C(Cl)C=C2)C3=C4C=CC=C3)C4=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)
Target
– Apoptosis;Caspase;PARP
Isoform
– Caspase 3;Caspase 9;PARP1
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
