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Products Details
Product Description
– PARP-1/HDAC-IN-1 is a PARP-1/HDAC6 dual targeting inhibitor with IC50s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities[1].
Web ID
– HY-146160
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H18N4O4
References
– [1]Ziwei Chi, et al. Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors. Bioorg Med Chem Lett. 2022 Sep 1;71:128821.
Molecular Weight
– 402.40
SMILES
– NC(C1=CC=CC2=CN(N=C21)C3=CC=C(C=C3)OCC4=CC=C(C=C4)C(NO)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;PARP
Isoform
– HDAC2;HDAC3;HDAC6;PARP1
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
