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Products Details
Product Description
– PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy[1].
Web ID
– HY-152265
Shipping
– Room temperature
Molecular Formula
– C40H58N6O7
References
– [1]Poláchová E, et, al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023 Jan 12;66(1):251-265.
Molecular Weight
– 734.92
SMILES
– O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(C(CNCCCCC1=CC=CC=C1)=O)=O)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O)C
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Mitophagy
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
