Download Files:
Pardoprunox (hydrochloride)
$420 – $2,520
Products Details
Product Description
– Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].
Web ID
– HY-14958A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C12H16ClN3O2
References
– [1]Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608.|[2]Jones CA, et al. An in vivo pharmacological evaluation of pardoprunox (SLV308)–a novel combined dopamine D(2)/D(3) receptor partial agonist and 5-HT(1A) receptor agonist with efficacy in experimental models of Parkinson’s disease. Eur Neuropsychopharmacol. 2010 Aug;20(8):582-593.
CAS Number
– 269718-83-4
Molecular Weight
– 269.73
Compound Purity
– 98.89
SMILES
– O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1.[H]Cl
Clinical Information
– Phase 3
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 150 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Adrenergic Receptor;Dopamine Receptor
Isoform
– 5-HT1 Receptor;D2 Receptor;D3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
