Download Files:
pan-HER-IN-2
$90 – $1,350
Products Details
Product Description
– pan-HER-IN-2 (Compound C6) is a reversible, orally active pan-HER inhibitor with IC50 values of 0.72, 2.0, 8.2 and 75.1 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-2 induces apoptosis and shows antitumor activities[1].
Web ID
– HY-144677
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H15BrClN5O
References
– [1]Tang Q, et al. Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249.
CAS Number
– 1639040-95-1
Molecular Weight
– 444.71
Compound Purity
– 98.10
SMILES
– O=C(NC1=CC=C2N=CN=C(C2=C1)NC3=CC4=C(NC=C4Br)C=C3)CCCl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2;ErbB4/HER4
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
