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Products Details
Product Description
– pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities[1].
Web ID
– HY-144676
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H14BrN5O
References
– [1]Tang Q, et al. Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249.
CAS Number
– 1639040-94-0
Molecular Weight
– 408.25
SMILES
– C=CC(NC1=CC=C2N=CN=C(C2=C1)NC3=CC4=C(NC=C4Br)C=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2;ErbB4/HER4
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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