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Palonosetron (hydrochloride)
$79 – $165
Products Details
Product Description
– Palonosetron hydrochloride is a 5-HT3 antagonist that inhibits chemotherapy-induced nausea and vomiting (CINV).
Web ID
– HY-A0021
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H25ClN2O
References
– [1]Vishnu Murthy M, Srinivas K, Kumar R, Mukkanti K.
Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase.
J Pharm Biomed Anal. 2011 Sep 10;56(2):429-35.|[2]Ajioka H, Morita F, Akizawa Y, Yoshida K, Kitamura R, Takimoto H.
Pharmacological, pharmacokinetic, and clinical profile of palonosetron hydrochloride (ALOXI I.V. Injection 0.75 mg), a novel antiemetic 5-HT3-receptor antagonist.Nihon Yakurigaku Zasshi. 2010 Aug;136(2):113-20.|[3]Ruhlmann C, Herrstedt J.
Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting.
Expert Rev Anticancer Ther. 2010 Feb;10(2):137-48.|[4]Trissel LA, Trusley C, Ben M, Kupiec TC.
Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration.
Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13.|[5]Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists.J. Med. Chem., 1993, 36 (18), pp 2645-2657
CAS Number
– 135729-62-3
Molecular Weight
– 332.87
Compound Purity
– 99.96
SMILES
– O=C1N(C[C@@]([H])(CCC2)C3=C2C=CC=C13)[C@@H]4CN5CCC4CC5.[H]Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : 3.33 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– 5-HT Receptor
Isoform
– 5-HT3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
