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Palonosetron-d3 (hydrochloride)
$575
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Products Details
Product Description
– Palonosetron-d3 (hydrochloride) is the deuterium labeled Palonosetron hydrochloride. Palonosetron hydrochloride is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)[1][2].
Web ID
– HY-A0021S
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H22D3ClN2O
References
– [1]Vishnu Murthy M, Srinivas K, Kumar R, Mukkanti K.
Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase.
J Pharm Biomed Anal. 2011 Sep 10;56(2):429-35.|[2]Ajioka H, Morita F, Akizawa Y, Yoshida K, Kitamura R, Takimoto H.
Pharmacological, pharmacokinetic, and clinical profile of palonosetron hydrochloride (ALOXI I.V. Injection 0.75 mg), a novel antiemetic 5-HT3-receptor antagonist.Nihon Yakurigaku Zasshi. 2010 Aug;136(2):113-20.|[3]Ruhlmann C, Herrstedt J.
Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting.
Expert Rev Anticancer Ther. 2010 Feb;10(2):137-48.|[4]Trissel LA, Trusley C, Ben M, Kupiec TC.
Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration.
Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13.|[5]Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists.J. Med. Chem., 1993, 36 (18), pp 2645-2657|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1246816-81-8
Molecular Weight
– 335.89
SMILES
– O=C1C2=C3[C@@](C(N1[C@]4(C5CCN(C4)CC5)[2H])([2H])[2H])(CCCC3=CC=C2)[H].Cl
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Isotope-Labeled Compounds
Pathway
– GPCR/G Protein;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
