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Products Details
Product Description
– Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells[1][2].
Web ID
– HY-120911
Shipping
– Room temperature
Molecular Formula
– C23H36O4
References
– [1]Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.|[2]Dekker FJ, et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol. 2010 Jun;6(6):449-56.
CAS Number
– 1233365-12-2
Molecular Weight
– 376.53
SMILES
– O=C1O[C@@H](CCC2=CC=C(OC)C(OC)=C2)[C@@H]1CCCCCCCCCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Phospholipase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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