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Products Details
Product Description
– Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
Web ID
– HY-114577
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C8H22Cl2N3O5P
References
– [1]Jones B, Komarnitsky P, Miller GT, Amedio J, Wallner BP. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012;23(2):173-184.
CAS Number
– 1070409-31-2
Molecular Weight
– 342.16
SMILES
– O=P(NCCCl)(NCCCl)O.NC(CO)(CO)CO
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA Alkylator/Crosslinker
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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