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Palbociclib-propargyl
$880
Only 1000 item(s) left in stock.
Products Details
Product Description
– Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1]. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-130296
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H31N7O2
References
– [1]Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.
CAS Number
– 2366269-23-8
Molecular Weight
– 485.58
Compound Purity
– 95.23
SMILES
– O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCN(CC#C)CC4)C=C3)N=C2N1C5CCCC5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Ligands for Target Protein for PROTAC
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
