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PAK4-IN-3
SKU
HY-156453-Get quote
Category Reference compound
Tags Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton, Apoptosis;PAK, Cancer
Products Details
Product Description
– PAK4-IN-3(compound 27e) is aPAK4inhibitor, with theIC50of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC50value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1[1].
Web ID
– HY-156453
Shipping
– Room temperature
Molecular Formula
– C21H22ClN7O
References
– [1]Han W, et al. Design, synthesis and anticancer activity evaluation of 4-(3-1H-indazolyl)amino quinazoline derivatives as PAK4 inhibitors [published online ahead of print, 2023 Oct 13]. Bioorg Med Chem. 2023;95:117501.
Molecular Weight
– 423.90
SMILES
– N[C@H](C(C)C)CNC(C1=NC2=CC=C(C=C2C(NC3=NNC4=C3C=CC=C4)=N1)Cl)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PAK
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.