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Products Details
Product Description
– PAK4-IN-1 (Compound 19) is a potent, selective, orally active PAK4 inhibitor with robust anti-tumor efficacy in vivo. PAK4-IN-1 is stable under both acidic and neutral conditions[1].
Web ID
– HY-130628
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H30ClN7O5
References
– [1]Jing Guo, et al. Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor. Eur J Med Chem. 2020 Jan 15;186:111878.
CAS Number
– 2396529-58-9
Molecular Weight
– 556.01
SMILES
– O=C(OCOC(C(C)C)=O)N1[C@@H](CN(CC1)C(C2=NC(NC3=NNC(C4CC4)=C3)=C5C=C(C=CC5=N2)Cl)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PAK
Isoform
– PAK4
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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