Products Details

Product Description

– PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

Web ID

– HY-146681

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C26H20ClN5O2

References

– [1]Zhang M, et al. Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities. Eur J Med Chem. 2020 Oct 1;203:112517.

CAS Number

– 2485732-30-5

Molecular Weight

– 469.92

SMILES

– CC1=CC=CN(C1=O)C2=CC=C(C(Cl)=C2)C3=CC=C4C(NN=C4C(NCC5=CC=NC=C5)=O)=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– PAK

Isoform

– PAK1;PAK4

Pathway

– Cell Cycle/DNA Damage;Cytoskeleton

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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