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Products Details
Product Description
– PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].
Web ID
– HY-157157
Shipping
– Room temperature
Molecular Formula
– C21H26BClN4O4
References
– [1]Jia Y et al. Chitosan nanomedicine containing RGD peptide and PAD4 inhibitor based on phenyl boronate coupling inhibition of primary tumor growth and lung metastasis. Biomed Pharmacother. 2023 Dec;168:115826.
CAS Number
– 2642327-44-2
Molecular Weight
– 444.72
SMILES
– O=C(NCC1=CC=CC=C1)[C@H](CCCNC(CCl)=N)NC(C2=CC(B(O)O)=CC=C2)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Protein Arginine Deiminase
Pathway
– Epigenetics
Product type
– Reference compound
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