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PAβN (dihydrochloride)
$60 – $504
Products Details
Product Description
– PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
Web ID
– HY-101444A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H32Cl2N6O2
Citations
– bioRxiv. 2020 Apr.|Front Cell Infect Microbiol. 2021 Mar 25;11:660431.|J Antimicrob Chemother. 2021 Oct 11;dkab375.|Microb Drug Resist. 2020 Jun;26(6):550-560.|Microb Pathog. 2023 Oct 16:106397.|mSphere. 2023 Feb 28;e0067322.|Microbiol Spectr. 2023 Apr 18;e0308022.
References
– [1]Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16.|[2]Kurin?i? M, et al. Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. Microb Drug Resist. 2012 Oct;18(5):492-501.|[3]Lamers RP, et al. The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. PLoS One. 2013;8(3):e60666.
CAS Number
– 100929-99-5
Molecular Weight
– 519.47
Compound Purity
– 99.89
SMILES
– O=C([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)N)=O)NC2=CC(C=CC=C3)=C3C=C2.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)|H2O : 14.29 mg/mL (ultrasonic)
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
