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Products Details
Product Description
– p53-HDM2-IN-1 is a potent inhibitor of p53-HDM2 protein-protein interaction, with an IC50 of 0.103 μM. p53-HDM2-IN-1 can be used for the research of cancer[1].
Web ID
– HY-145907
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C35H38F6N4O7S
References
– [1]Tian Y, et, al. Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability. Bioorg Med Chem Lett. 2022 Apr 1;61:128625.
Molecular Weight
– 772.75
SMILES
– CCC[C@H]1N(CCC[C@@]1(OC2=CSC(C(F)(F)F)=C2)C(N3CCN(CC3)C4=CC=CC=C4OCCCC(O)=O)=O)C(C5=C(C=CN=C5O)C(F)(F)F)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
