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p53 Activator 7
$300 – $1,300
Products Details
Product Description
– p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)[1]. p53 Activator 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-148416
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H32F3N4OP
References
– [1]Sujing LI, et al. Compounds targeting y220c mutant of p53. WO2022213975A1.
CAS Number
– 2849340-59-4
Molecular Weight
– 516.54
Compound Purity
– 98.52
SMILES
– FC(F)(F)CN1C2=C(C(NC3CCN(CC3)C)=CC=C2)C=C1C#CCNC4=CC=C(P(C)(C)=O)C=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
