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p53 Activator 5
$600 – $2,600
Products Details
Product Description
– p53 Activator 5 (compound 134A) is a potent p53 activator with a SC150 value of <0.05 mM. p53 Activator 5 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 5 shows anti-tumor activity[1]. p53 Activator 5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-148404
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H32F6N4O
References
– [1]VU, Binh, et al. Methods and compounds for restoring mutant p53 function, WO2021061643.
CAS Number
– 2636840-37-2
Molecular Weight
– 566.58
SMILES
– COC1=CC(C(F)(F)F)=CC=C1NCC#CC2=CC3=C(C=CC=C3N[C@@H](CC4)CC[C@H]4N(C)C)N2CC(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
