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Products Details
Product Description
– p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].
Web ID
– HY-147518
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C37H49N11O2
References
– [1]Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65(10):7170-7192.
CAS Number
– 1443242-46-3
Molecular Weight
– 679.86
SMILES
– O=C(N[C@H]1CC[C@H](C2=C1C=CC=C2)OC(C=C3)=CN4C3=NN=C4N5[C@H](CCCC5)C)NC6=CC(C(C)(C)C)=NN6C7=CN(N=C7)CCN(C)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– p38 MAPK
Isoform
– p38α;p38β;p38γ;p38δ
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
