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Products Details
Product Description
– p38-α MAPK-IN-4 (Compound 69) is a selective p38α MAPK inhibitor with an IC50 of 1.5 µM. p38-α MAPK-IN-4 rapidly and strongly prevents the development of mechanical allodynia (MA) in vivo[1].
Web ID
– HY-146032
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H13BrN2O
References
– [1]Visseq A, et al. Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia. Eur J Med Chem. 2020 Feb 1;187:111917.
CAS Number
– 2396754-57-5
Molecular Weight
– 341.20
SMILES
– O=C1C(C2=CC=CC=C2Br)=CC(NC3=CC=CC=C3)=CN1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– p38 MAPK
Isoform
– p38α
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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