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Product Description
– p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ[1].
Web ID
– HY-14412
Shipping
– Room temperature
Molecular Formula
– C14H7F6N3O
References
– [1]ACS Chem. Biol., Article ASAP
DOI: 10.1021/cb1002619
Publication Date (Web): November 23, 2010|[2]Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.
CAS Number
– 1262406-08-5
Molecular Weight
– 347.22
SMILES
– O=C1C=C(C(F)(F)F)C2=C(NN=C2C3=CC(C(F)(F)F)=CC=C3)N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– p38 MAPK
Isoform
– p38α
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
