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Products Details
Product Description
– p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ[1].
Web ID
– HY-14412
Shipping
– Room temperature
Molecular Formula
– C14H7F6N3O
References
– [1]ACS Chem. Biol., Article ASAP
DOI: 10.1021/cb1002619
Publication Date (Web): November 23, 2010|[2]Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.
CAS Number
– 1262406-08-5
Molecular Weight
– 347.22
SMILES
– O=C1C=C(C(F)(F)F)C2=C(NN=C2C3=CC(C(F)(F)F)=CC=C3)N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– p38 MAPK
Isoform
– p38α
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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