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Products Details
Product Description
– P300 bromodomain-IN-1 (Compoun 1u) is a potent p300 (EP300) bromodomain inhibitor with an IC50 of 49 nM. P300 bromodomain-IN-1 suppresses the expression of c-Myc and induces G1/G0 phase arrest and apoptosis in OPM-2 cells[1].
Web ID
– HY-146445
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H31ClN4O4
References
– [1]Chen Z, et al. Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells. Bioorg Med Chem. 2022 Jul 15;66:116784.
Molecular Weight
– 535.03
SMILES
– COC1=CC=C(C=C1Cl)N2C(C[C@H]2C3=NC4=CC(C5=C(ON=C5C)C)=CC=C4N3[C@H]6CC[C@@H](CC6)OC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain;Histone Acetyltransferase
Isoform
– CBP/p300
Pathway
– Epigenetics
Product type
– Reference compound
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