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Products Details
Product Description
– P300 bromodomain-IN-1 (Compoun 1u) is a potent p300 (EP300) bromodomain inhibitor with an IC50 of 49 nM. P300 bromodomain-IN-1 suppresses the expression of c-Myc and induces G1/G0 phase arrest and apoptosis in OPM-2 cells[1].
Web ID
– HY-146445
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H31ClN4O4
References
– [1]Chen Z, et al. Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells. Bioorg Med Chem. 2022 Jul 15;66:116784.
Molecular Weight
– 535.03
SMILES
– COC1=CC=C(C=C1Cl)N2C(C[C@H]2C3=NC4=CC(C5=C(ON=C5C)C)=CC=C4N3[C@H]6CC[C@@H](CC6)OC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain;Histone Acetyltransferase
Isoform
– CBP/p300
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
