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P2Y2R/GPR17 antagonist 1
$94 – $720
Products Details
Product Description
– P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].
Web ID
– HY-146486
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H13ClN2O6S
References
– [1]Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.
CAS Number
– 2395016-49-4
Molecular Weight
– 432.83
Compound Purity
– 98.85
SMILES
– O=C(C1=C(C=CC=C1)Cl)NC2=CC=C(C=C2)S(=O)(OC3=CC([N+]([O-])=O)=CC=C3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– P2Y Receptor
Isoform
– P2Y2 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
