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Product Description
– P-gp inhibitor 2 is a potent P-gp inhibitor. P-gp inhibitor 2 shows reverse Doxorubicin resistance (IC50=0.22 µM) in P-gp overexpressing human colorectal carcinoma cells (SW600 Ad300)[1].
Web ID
– HY-N144114
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H26N2O6
References
– [1]Dewa AA, et al. Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore. J Med Chem. 2022, 65(3):2610-2622.
CAS Number
– 2408406-89-1
Molecular Weight
– 498.53
SMILES
– O=C1N2[C@@](CN([C@H](C2)C(C3=CC=CC=C3)=O)C(C)=O)([H])[C@](C4=CC(OC)=C(OCO5)C5=C4)([H])C6=CC=CC=C61
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– P-glycoprotein
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
