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Products Details
Product Description
– P-gp/BCRP-IN-1 (compound 19) is a potential, relatively safe, orally active and efficient efflux transporter (P-gp and BCRP) inhibitor. P-gp/BCRP-IN-1 exerts resistance reversal by inhibiting the efflux function of P-gp and BCRP. P-gp/BCRP-IN-1 can overcome the resistance and improve the oral bioavailability of PTX (Paclitaxel)[1].
Web ID
– HY-144393
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H25ClN4O3
References
– [1]Shi W, Zhang P, Zou F, et al. Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel. Eur J Med Chem. 2022;233:114231.
CAS Number
– 2764596-06-5
Molecular Weight
– 488.97
SMILES
– O=C(C1=NN(C(C2=CC=CC=C21)=O)C3=CC=C(C=C3)Cl)NC4=CC=C(C=C4)CCN5CCOCC5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– BCRP
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
