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Products Details
Product Description
– Oxyphenbutazone-d9 is the deuterium labeled Oxyphenbutazone (HY-B1355A). Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2][3].
Web ID
– HY-B1355AS
Shipping
– Room temperature
Molecular Formula
– C19H11D9N2O3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196.|[3]Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11.
CAS Number
– 1189693-23-9
Molecular Weight
– 333.43
SMILES
– O=C1N(C2=CC=C(C=C2)O)N(C3=CC=CC=C3)C(C1C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Bacterial;COX;Isotope-Labeled Compounds
Pathway
– Anti-infection;Immunology/Inflammation;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
