Products Details

Product Description

– Oxyphenbutazone-13C6 is the 13C6 labeled Oxyphenbutazone (HY-B1355A). Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2].

Web ID

– HY-B1355AS1

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C13 13C6H20N2O3

References

– [1]Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11.|[2]Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight

– 330.33

SMILES

– O=C(C1CCCC)N([13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)N(C3=CC=C(O)C=C3)C1=O

Clinical Information

– No Development Reported

Research Area

– Cancer; Infection; Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Bacterial;COX;Isotope-Labeled Compounds

Pathway

– Anti-infection;Immunology/Inflammation;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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