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Product Description
– Oxprenolol-d7 is the deuterium labeled Oxprenolol. Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].
Web ID
– HY-B1486AS
Shipping
– Room temperature
Molecular Formula
– C15H16D7NO3
References
– [1]T Nagatomo, et al. Binding Characteristics of <sup>3</sup>H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7.|[2]A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1189805-10-4
Molecular Weight
– 272.39
SMILES
– [2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])NCC(O)COC1=C(C=CC=C1)OCC=C
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;Isotope-Labeled Compounds
Pathway
– GPCR/G Protein;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
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