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Oteseconazole

SKU HY-17643-10 mg Category Reference compound Tags Anti-infection;Metabolic Enzyme/Protease, Cytochrome P450;Fungal, Infection

$350 – $1,650

Size10 mg

5 mg 10mM/1mL 10 mg 25 mg 50 mg

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Products Details

Product Description

– Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51[1][2].

Web ID

– HY-17643

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C23H16F7N5O2

References

– [1]Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7.|[2]Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.

CAS Number

– 1340593-59-0

Molecular Weight

– 527.39

Compound Purity

– 99.56

SMILES

– O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OCC(F)(F)F)C=C4)C=N3)F

Clinical Information

– Launched

Research Area

– Infection

Solubility

– DMSO : 250 mg/mL (ultrasonic)

Target

– Cytochrome P450;Fungal

Isoform

– CYP51

Pathway

– Anti-infection;Metabolic Enzyme/Protease

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.