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Product Description
– Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].
Web ID
– HY-136346S
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C33H28D5FN2O5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790.|[3]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.
CAS Number
– 265989-50-2
Molecular Weight
– 561.65
SMILES
– OC(C=CC=C1)=C1NC(C2=C(C(C)C)N(CC[C@@H]3C[C@H](CC(O3)=O)O)C(C4=CC=C(C=C4)F)=C2C5=C([2H])C([2H])=C([2H])C([2H])=C5[2H])=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
