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Opiorphin

SKU HY-W345510-Get quote Category Peptides Tags Metabolic Enzyme/Protease, Neprilysin, Neurological Disease

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Products Details

Product Description

– Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2].

Web ID

– HY-W345510

Shipping

– Room temperature

Molecular Formula

– C29H48N12O8

References

– [1]Wisner A, et, al. Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17979-84.|[2]Tian XZ, et, al. Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice. Peptides. 2009 Jul;30(7):1348-54.

CAS Number

– 864084-88-8

Molecular Weight

– 692.77

SMILES

– OC[C@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)N)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– 10 mM in DMSO

Target

– Neprilysin

Pathway

– Metabolic Enzyme/Protease

Product type

– Peptides

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.