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Products Details
Product Description
– ONO-3403 is an orally active serine protease inhibitor. ONO-3403 inhibits the production of TNF-α and nitric oxide induced by LPS. ONO-3403 inhibits the cell growth and induces the apoptosis, and has an antitumor effect on malignant tumors[1][2][3][4].
Web ID
– HY-123542
Shipping
– Room temperature
Molecular Formula
– C26H31N3O8S
References
– [1]Tumurkhuu G, et al. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011;17(1):97-105.|[2]Hiwasa T, et al. Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines. Cancer Lett. 1998;126(2):221-225.|[3]Ohkoshi M, et al. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002;22(2A):821-823.
CAS Number
– 181586-07-2
Molecular Weight
– 545.60
SMILES
– O=C(C1=CC=C(C=C1)/C=C(C(N(CC=C)CC(OCC)=O)=O)C)OC2=CC=C(C=C2)C(N)=N.CS(=O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Ser/Thr Protease
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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