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ONO-0300302
$220 – $5,400
Products Details
Product Description
– ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1].
Web ID
– HY-115450
Storage Temperature
– -20°C (Powder, protect from light)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C29H35NO5
References
– [1]Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286.
CAS Number
– 856689-51-5
Molecular Weight
– 477.59
Compound Purity
– 99.43
SMILES
– O=C(O)CCC1=CN(C[C@H](CC2CC3=C(C=CC=C3)C2)[C@@H](C4=CC(OC)=C(C)C(OC)=C4)O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology
Solubility
– DMSO : 220 mg/mL (ultrasonic)
Target
– LPL Receptor
Isoform
– LPAR1
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
